25^th American Dental Research & Future Dentistry

Objective: To study and compare the efficacy of Vizilite®Plus and computer-assisted brush biopsy (Oral CDx), a non-invasive adjuvant diagnostic aids, in the detection and assessment of oral potentially malignant, and/or malignant lesions.

 

Study Design: This is a prospective study that included a total of 500 patients referred to Oral Medicine clinics of King Abdulaziz University Faculty of

Dentistry (KAUFD), and regional Ministry of Health (MOH) hospitals, presenting with oral mucosal lesions over a 24-month period which were referred for further management. All cases were examined with Vizilite®Plus.

Cases with positive results were subjected to Oral CDx. Positive or atypical Oral CDx lesions, as well as negative Oral CDx lesions with clinical suspicion of precancer/ malignancy, were scalpel biopsied.

 

Results: The sensitivity of Vizilite®Plus in detecting dysplasia/malignancy was

100% whereas the specificity was 30.3%. The positive predictive value was 19.29%, whereas the negative predictive value was 100%. The positive

likelihood ratio was 1.43 and the negative likelihood ratio was 0. The sensitivity of Oral CDx in detecting dysplasia/malignancy was 97.4%, whereas

the specificity was 78.94%. The positive predictive value was 52.44% whereas the negative predictive value was 99.22%. The positive likelihood ratio was 4.6

and the negative likelihood ratio was 0.03.

 

Conclusions: Because of its low positive and negative predictive values, we do not advocate Vizilite®Plus as a useful adjunctive tool for the diagnosis of oral cancer. Oral CDx is more promising and can be utilized as an aid for the early diagnosis of suspicious oral lesions with limitations.