Nicka Aghamohammadi
Shahid Beheshti University of Medical Sciences and Health Services, Iran
Title: Natural resistanceassociated macrophage protein 1 gene polymorphism is associated with chronic periodontitis not periimplantitis in an Iranian population: A crosssectional study
Biography
Biography: Nicka Aghamohammadi
Abstract
In inflammatory diseases such as peri-implantitis (PI) and chronic periodontitis (CP), both adaptive and innate immunity play a part. Natural resistanceassociated macrophage protein 1(Nramp1) has considerable effects on macrophage function (phagocytosis) and host innate immune response against infections. The present study was to investigate the relationship of Nramp1 gene polymorphisms with PI and CP in an Iranian population. In this crosssectional study 79 patients with CP, 38 patients with PI and 84 healthy controls presenting to the Periodontology Department of Shahid Beheshti University of Medical Sciences were enrolled. DNA was extracted from fresh blood samples of arm vein of participants and transferred to the KBiosience Institute (United Kingdom) for genotyping. χ2 and Fisher’s exact tests were
used by SPSS software v.19 for statistical analyses. Significant differences were detected in the distribution of genotypes between control and CP groups
both for rs17235409 and rs2276631 polymorphisms (P:0.044 and P:0.028
respectively). Distribution of genotypes differed insignificantly in comparison of PI and control groups for rs2276631 (P:0.623) and either rs17235409 (P:1)
polymorphisms. Based on our results, we conclude that the presence of G allele in both rs2276631 and rs17235409 location may be a protective factor against CP. More studies with a larger sample size in different populations are required for confirming Nramp1 as a genetic determinant in periodontal disorders.