25^th American Dental Research & Future Dentistry

A series of synthetic, inorganic, osteoconductive/ osteoinductive and fully resorbable Ca/P/S-based bone substitute devices have been developed by a joint research project of National Cheng-Kung University and Joy Medical Devices Corporation of Taiwan. The granular type product (Ezechbone® Granule) is a highly porous material characterized by its non-inflammation, high resorption, and fast healing capability. The cement type product (Ezechbone® Cement) is featured by its non-inflammatory, injectable and non dispersive behavior in blood/body fluid in paste form. The safety and efficacy of these devices have been confirmed by a series of chemical/ physical characterization and biocompatibility tests. The animal models for implantation tests include the SD rat femur body, New Zealand white rabbit femur condyle and mandible, Lanyu pig mandible and osteoporotic goat spine. The rabbit condyle implantation/histopathologic examination indicates that the implants of both types are always intimately integrated with the surrounding bone substantially without a foreign body or other undesirable tissue reactions. The porous Ezechbone® Granule outperforms autologous bone by its less inflammatory/ irritative tissue response and higher new bone formation rate, especially at the critical early stage post-implantation. Clinical case reports covered in this presentation include dental ridge augmentation, sinus lift, sternum closure, frontal bone augmentation and treatment of various types of fractures.